4 Methyl Uracil Chemical Properties are foundational to understanding its applications in pharmaceuticals, agrochemicals, and fine chemical synthesis—making it a high-value intermediate for industries worldwide. As a leading manufacturer of pyrimidine derivatives, Hebei Guangxing Chemical Co., Ltd. specializes in the production of high-purity 4 methyl uracil, leveraging its expertise in optimizing 4 methyl uracil synthesis and analyzing 4 methyl uracil structure to meet strict industry standards. The company’s ISO 9001-certified production lines ensure 4 methyl uracil meets chromatographic purity ≥99.5% and low heavy metal content (≤1 ppm), critical for pharmaceutical and cosmetic applications. By integrating advanced analytical techniques (HPLC, NMR) to characterize 4 methyl uracil structure and refine synthesis conditions, Hebei Guangxing has become a reliable supplier of this compound, supporting clients in developing drugs, UV absorbers, and specialty additives.
Physical & Chemical Traits for 4 methyl uracil
- Physical State & Appearance: Hebei Guangxing’s 4 methyl uracil is a white to off-white crystalline powder with a uniform particle size (100–200 μm), ensuring easy handling and dispersion in formulations. Unlike raw uracil, 4 methyl uracil has a lower hygroscopicity (moisture absorption ≤0.5% at 25°C, 60% RH), reducing clumping during storage and extending shelf life to 2 years under proper conditions (sealed, cool dry place).
- Melting & Thermal Stability: 4 methyl uracil has a melting point of 328–332°C (decomposition), as verified by differential scanning calorimetry (DSC) at Hebei Guangxing’s in-house lab. It maintains thermal stability up to 280°C without decomposition, making it suitable for high-temperature synthesis processes (e.g., pharmaceutical intermediate reactions) where lower-stability compounds would degrade.
- Solubility Characteristics: 4 methyl uracil exhibits selective solubility—slightly soluble in water (2.5 g/L at 25°C) and ethanol (1.8 g/L at 25°C), but highly soluble in dimethyl sulfoxide (DMSO, ≥50 g/L) and hot acetic acid. Hebei Guangxing provides solubility data tailored to client needs, helping formulate 4 methyl uracil into liquid pharmaceutical preparations or solid dosage forms (e.g., tablets) with optimal bioavailability.
Molecular Structure Analysis for 4 methyl uracil structure
- Chemical Formula & Molecular Weight: The 4 methyl uracil structure is defined by the formula C₅H₆N₂O₂ and molecular weight 126.11 g/mol, confirmed by Hebei Guangxing’s elemental analysis (C: 47.61%, H: 4.80%, N: 22.21%, O: 25.38%—matching theoretical values). This structure differs from uracil by a methyl group (-CH₃) at the 4-position of the pyrimidine ring, a modification that alters its reactivity and solubility.
- Functional Group Characteristics: 4 methyl uracil structure contains two carbonyl groups (C=O) at positions 2 and 6, and an amino group (-NH-) at position 3—key functional groups that enable reactions like alkylation, acylation, and hydrogenation. Hebei Guangxing uses nuclear magnetic resonance (¹H NMR, ¹³C NMR) to confirm these groups, with spectra showing characteristic peaks (e.g., δ 2.05 ppm for the 4-methyl proton, δ 11.2 ppm for the NH proton) that validate 4 methyl uracil structure
- Crystalline Structure: X-ray diffraction (XRD) analysis by Hebei Guangxing reveals that 4 methyl uracil structure forms a monoclinic crystal system with a space group of P2₁/c. This crystalline arrangement contributes to its high melting point and low solubility in water, as the tight packing of molecules reduces interactions with solvent molecules—critical information for clients optimizing crystallization processes in downstream applications.
Industrial Synthesis Process for 4 methyl uracil synthesis
- Raw Material & Catalyst Selection: Hebei Guangxing’s 4 methyl uracil synthesis uses ethyl acetoacetate and urea as raw materials, reacting in the presence of a weak acid catalyst (e.g., acetic acid) to avoid harsh reaction conditions. The molar ratio of ethyl acetoacetate to urea is optimized to 1:1.2, maximizing 4 methyl uracil yield (≥88%) while minimizing byproducts (e.g., unreacted urea, ethyl acetate).
- Reaction Conditions: 4 methyl uracil synthesis occurs at 120–130°C under atmospheric pressure, with a reaction time of 4–5 hours. Hebei Guangxing uses a jacketed reactor with precise temperature control (±1°C) to ensure consistent product quality across batches. Unlike high-pressure synthesis methods, this mild process reduces energy consumption by 30% and lowers equipment costs, making industrial-scale production more economical.
- Purification & Recovery: After synthesis, 4 methyl uracil is purified via recrystallization from hot water (80–85°C), followed by centrifugal filtration and vacuum drying (60°C, -0.09 MPa). This process removes impurities to ≤0.3%, achieving chromatographic purity ≥99.5%. Hebei Guangxing recycles the mother liquor from recrystallization, recovering an additional 5–7% of 4 methyl uracil and reducing waste discharge—aligning with the company’s ISO 14001 environmental standards.
4 Methyl Uracil FAQS
What is the purity of Hebei Guangxing’s 4 methyl uracil, and how is it verified?
Hebei Guangxing’s 4 methyl uracil has a chromatographic purity of ≥99.5%, verified by high-performance liquid chromatography (HPLC) using a C18 column (mobile phase: water-acetonitrile = 90:10, flow rate: 1.0 mL/min). Additional tests (elemental analysis, NMR) confirm impurity content ≤0.5% and 4 methyl uracil structure integrity. Batch-specific COAs (Certificates of Analysis) are provided to clients, ensuring the product meets pharmaceutical-grade standards for applications like drug intermediate synthesis.
How does 4 methyl uracil structure differ from uracil, and what impact does this have on its use?
The 4 methyl uracil structure has a methyl group (-CH₃) at the 4-position of the pyrimidine ring, whereas uracil has a hydrogen atom at this position. This modification reduces hygroscopicity (4 methyl uracil absorbs 0.5% moisture vs. uracil’s 1.2%) and increases thermal stability (melting point 328–332°C vs. uracil’s 295°C). These traits make 4 methyl uracil better suited for high-temperature pharmaceutical synthesis and long-term storage, where uracil might degrade or clump.
What is the yield of Hebei Guangxing’s 4 methyl uracil synthesis process, and how is it optimized?
Hebei Guangxing’s 4 methyl uracil synthesis achieves a yield of ≥88%, optimized via three key factors: 1) Molar ratio of ethyl acetoacetate to urea (1:1.2) to minimize unreacted raw materials; 2) Mild acid catalyst (acetic acid) to avoid side reactions; 3) Recycle of mother liquor to recover additional product. This yield is 10–15% higher than traditional synthesis methods, making 4 methyl uracil more cost-effective for large-scale client orders (≥5 tons).
Is 4 methyl uracil from Hebei Guangxing suitable for pharmaceutical applications?
Yes—Hebei Guangxing’s 4 methyl uracil meets pharmaceutical-grade requirements: heavy metal content (Pb/Cd/As ≤1 ppm), residual solvent (ethanol ≤500 ppm), and microbiological purity (total aerobic microbial count ≤100 CFU/g). Its high purity (≥99.5%) and well-characterized 4 methyl uracil structure (verified by NMR/XRD) make it suitable for use as an intermediate in anti-inflammatory drugs and dermatological formulations. A pharmaceutical client in Europe has used this product for 3 years with zero compliance issues.
Can Hebei Guangxing provide customized 4 methyl uracil synthesis parameters for specific client needs?
Absolutely—Hebei Guangxing offers customized 4 methyl uracil synthesis parameters (e.g., particle size 50–300 μm, solubility modifiers) to meet client-specific applications. For example, a cosmetic client required finer 4 methyl uracil (50–80 μm) for UV absorber formulations; the company adjusted crystallization conditions to achieve this particle size without compromising purity. Technical support is also provided to optimize 4 methyl uracil integration into client processes, such as recommending solvent systems for dissolution.
Hebei Guangxing Chemical Co., Ltd. was established in January 2013 and is located in the ChemicalIndustrial Park of Xinhe County, Xingtai City, Hebei Province, covering an area of 90 acres.calcium zinc stabilizer manufacturer The mainproducts are 5000 tons/vear 13-dimethylurea and 6000 tons/year 6-amino-13-dimethyluracil.Hebei Guangxing Chemical Co., Ltd. was established in January 2013 and is located in the ChemicalIndustrial Park of Xinhe County, Xingtai City, Hebei Province, covering an area of 90 acres.pvc heat stabilizers The mainproducts are 5000 tons/vear 13-dimethylurea and 6000 tons/year 6-amino-13-dimethyluracil.uracils|super blog