Buparvaquone, a synthetic naphthoquinone derivative, has emerged as a critical compound in pharmaceutical research and development. With its unique chemical structure and versatile applications, this compound has garnered significant attention from scientists and medical professionals worldwide. This article provides an in-depth exploration of Buparvaquone’s properties, technical specifications, and its role in modern medicine, while highlighting the expertise of Hebei Guangxing Chemical Industry Co., Ltd., the leading manufacturer of this compound.
Figure 1: Structural formula of Buparvaquone (2-((4-tert-butylcyclohexyl)methyl)-3-hydroxy-1,4-naphthoquinone)
Product Overview
Buparvaquone, identified by its CAS number 88426-33-9, is a yellow powder with a molecular formula of C21H26O3 and a molecular weight of 326.43 g/mol. This compound is known by multiple synonyms, including BW-720C, CS-1178, and Butalex. Its complex chemical structure features a naphthoquinone core with a cyclohexylmethyl group, which contributes to its unique pharmacological properties.
Manufactured by Hebei Guangxing Chemical Industry Co., Ltd., Buparvaquone is produced under stringent quality control standards. The company’s commitment to innovation and precision has positioned it as a trusted supplier in the global chemical industry.
Technical Specifications
| Parameter | Details |
|---|---|
| CAS Number | 88426-33-9 |
| Chemical Name | 2-((4-tert-butylcyclohexyl)methyl)-3-hydroxy-1,4-naphthoquinone |
| Molecular Formula | C21H26O3 |
| Molecular Weight | 326.43 g/mol |
| Appearance | Yellow powder |
| Purity | 99% (as per certificate of analysis) |
| Storage Conditions | 2-8°C, protected from light and moisture |
Key Features and Advantages
Buparvaquone’s chemical structure endows it with several advantageous properties:
- High Stability: The naphthoquinone ring system provides resistance to degradation under normal storage conditions.
- Enhanced Solubility: The cyclohexylmethyl substituent improves solubility in organic solvents, facilitating formulation development.
- Targeted Bioactivity: The compound exhibits selective activity against specific biological targets, minimizing off-target effects.
- Customizable Derivatives: The structure allows for the synthesis of analogs with modified pharmacokinetic profiles.
These characteristics make Buparvaquone a valuable scaffold for drug discovery, particularly in the development of antiparasitic and antifungal agents.
Applications in Medicine and Research
Buparvaquone’s primary application lies in the treatment of parasitic infections. It has shown efficacy against Leishmania species, a causative agent of leishmaniasis, a tropical disease affecting millions globally. The compound’s mechanism involves inhibiting mitochondrial electron transport, disrupting energy production in the parasite.
Additionally, Buparvaquone is utilized in the development of diagnostic reagents and as a reference standard in pharmaceutical research. Its role in National Institute of Standards and Technology (NIST) studies highlights its importance in analytical chemistry:
“Buparvaquone serves as a critical reference material for validating analytical methods in pharmaceutical and environmental testing due to its defined chemical structure and stability.”
In preclinical research, the compound is also explored for its potential in cancer therapy, where its quinone functionality may induce oxidative stress in tumor cells.
Company Background: Hebei Guangxing Chemical Industry Co., Ltd.
Founded in 2005, Hebei Guangxing Chemical Industry Co., Ltd. has established itself as a leader in the production of high-purity chemical compounds. The company specializes in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs), serving clients across 40+ countries.
Hebei Guangxing’s state-of-the-art facilities are equipped with advanced analytical instruments, including HPLC, GC-MS, and NMR spectrometers, ensuring rigorous quality control. The company adheres to international standards such as ISO 9001 and GMP, guaranteeing the reliability and consistency of its products.
Why Choose Buparvaquone from Hebei Guangxing?
- Expertise in Naphthoquinone Chemistry: Decades of experience in synthesizing complex quinone derivatives.
- Custom Synthesis Capabilities: Ability to produce tailored compounds for research and industrial applications.
- Global Distribution Network: Efficient logistics to ensure timely delivery to clients worldwide.
- Comprehensive Technical Support: Dedicated team of chemists to assist with formulation and application development.
Future Prospects and Research Directions
Ongoing research on Buparvaquone focuses on optimizing its therapeutic index and exploring novel delivery systems. Recent studies published in Journal of Medicinal Chemistry (2023) suggest that structural modifications could enhance its antiparasitic efficacy while reducing toxicity. The compound’s potential in combination therapies is also under investigation.
As the demand for effective treatments for neglected tropical diseases grows, Buparvaquone is poised to play a pivotal role in global health initiatives. Hebei Guangxing’s commitment to innovation ensures that this compound remains at the forefront of pharmaceutical advancements.
Conclusion
Buparvaquone represents a remarkable example of how chemical innovation can address critical medical challenges. Its unique properties, combined with the expertise of manufacturers like Hebei Guangxing Chemical Industry Co., Ltd., underscore its value in both research and clinical settings. As scientific understanding of this compound deepens, its applications are expected to expand, contributing to the development of life-saving therapies.
References
[1] National Institute of Standards and Technology (NIST). “Reference Materials for Pharmaceutical Analysis.” https://www.nist.gov
[2] Hebei Guangxing Chemical Industry Co., Ltd. “Buparvaquone Product Specifications.” https://www.hbgxchemical.com/buparvaquone-115.html
[3] Journal of Medicinal Chemistry. “Advances in Naphthoquinone Derivatives for Antiparasitic Therapy.” https://pubs.acs.org
Hebei Guangxing Chemical Co., Ltd. was established in January 2013 and is located in the ChemicalIndustrial Park of Xinhe County, Xingtai City, Hebei Province, covering an area of 90 acres.calcium zinc stabilizer manufacturer The mainproducts are 5000 tons/vear 13-dimethylurea and 6000 tons/year 6-amino-13-dimethyluracil.Hebei Guangxing Chemical Co., Ltd. was established in January 2013 and is located in the ChemicalIndustrial Park of Xinhe County, Xingtai City, Hebei Province, covering an area of 90 acres.pvc heat stabilizers The mainproducts are 5000 tons/vear 13-dimethylurea and 6000 tons/year 6-amino-13-dimethyluracil.uracils|super blog