Industrial Scale Uracil Production Methods are critical for meeting global demand for uracil—a key intermediate in pharmaceuticals, agrochemicals, and polymer additives like pvc heat stabilizers. As a leading fine chemical manufacturer, Hebei Guangxing Chemical Co., Ltd. specializes in scalable uracil production, with a focus on the cost-effective and eco-friendly uracil synthesis from urea route. The company’s ISO 9001-certified production lines ensure uracil purity ≥99.0% (chromatographic purity), meeting the strict standards required for pvc heat stabilizers and pharmaceutical applications. By optimizing reaction conditions, recycling byproducts, and integrating advanced process control, Hebei Guangxing has scaled uracil production to 500 tons/year, making it a reliable supplier for industries relying on high-quality uracil—from pharmaceutical companies to manufacturers of pvc heat stabilizers seeking non-toxic, sustainable additives.

 

Urea-Based Synthesis for Uracil synthesis from urea

 

• Reaction Mechanism & Conditions: Hebei Guangxing’s uracil synthesis from urea process uses urea and malic acid (or malonate esters) as raw materials, reacting at 180–200°C under atmospheric pressure with a basic catalyst (e.g., sodium carbonate). The company optimizes the molar ratio of urea to malic acid (2.5:1) to maximize uracil yield (≥85%), reducing raw material waste. This mild reaction condition avoids high-pressure equipment, lowering capital costs for industrial-scale production—critical for scaling uracil synthesis from urea to hundreds of tons yearly.

 

• Byproduct Recycling: During uracil synthesis from urea, ammonium carbonate is a major byproduct. Hebei Guangxing recycles this byproduct into urea via reaction with CO₂ (captured from flue gas), cutting raw material consumption by 15% and reducing waste discharge. This circular economy approach aligns with the company’s ISO 14001 environmental certification, making uracil synthesis from urea an eco-friendly alternative to traditional cyanate-based methods.

 

• Continuous Production Design: Hebei Guangxing uses a continuous stirred-tank reactor (CSTR) system for uracil synthesis from urea, replacing batch reactors to enable 24/7 production. The CSTR system maintains stable temperature (±2°C) and catalyst concentration, ensuring consistent uracilquality across batches. This design has increased production efficiency by 40% compared to batch processes, supporting the company’s 500 tons/year uracil

 

Purification & Quality Control for Uracil

 

• Crystallization & Filtration: After synthesis, uracil is purified via cooling crystallization (cooling rate 5°C/hour) to form uniform crystals (particle size 100–200 μm), which are then filtered using a centrifugal filter (95% solid recovery rate). Hebei Guangxing optimizes crystallization conditions to remove impurities (e.g., unreacted urea, malic acid) to ≤0.5%, ensuring uracil purity meets pharmaceutical and pvc heat stabilizers standards (≥99.0%).

 

• Chromatographic Purification: For high-end applications (e.g., pharmaceutical-grade uracil), Hebei Guangxing adds a preparative HPLC step, further reducing impurities to ≤0.1%. The company uses a C18 column with water-acetonitrile mobile phase, achieving uracil recovery ≥98%—critical for clients requiring ultra-pure uracil for drug synthesis, while industrial-grade uracil (for pvc heat stabilizers) uses crystallization alone to balance cost and quality.

 

• Quality Testing Protocols: Every batch of uracil undergoes rigorous testing: chromatographic purity (HPLC, ≥99.0%), melting point (295±2°C, decomposed), loss on drying (≤1.0%), and heavy metal content (Pb/Cd/As ≤1 ppm). Hebei Guangxing provides batch-specific COAs (Certificates of Analysis) to clients, ensuring uracil meets their application needs—whether for pvc heat stabilizers (requiring low heavy metals) or pharmaceuticals (needing ultra-purity).

 

Application-Oriented Production for Pvc heat stabilizers

 

• Customized Particle Size: For pvc heat stabilizers manufacturers, Hebei Guangxing adjusts uracil particle size (80–300 μm) via controlled crystallization, ensuring good dispersion in PVC resin. Fine particles (80–150 μm) are ideal for flexible PVC (e.g., cables), while coarser particles (200–300 μm) suit rigid PVC (e.g., pipes). This customization prevents agglomeration in pvc heat stabilizers, maintaining consistent thermal stability (≥180 minutes at 180°C).

 

• Compatibility Enhancement: Hebei Guangxing modifies uracil surface with a small amount of stearic acid (0.5–1.0%) to improve compatibility with PVC and other stabilizer components (e.g., calcium zinc salts). This modification boosts the efficiency of pvc heat stabilizers, reducing the required uracil dosage by 10% while maintaining the same thermal protection—lowering costs for pvc heat stabilizers

 

• Batch Consistency for Stabilizer Production: Pvc heat stabilizers require consistent uracil quality to avoid performance fluctuations. Hebei Guangxing’s CSTR production and strict quality control ensure batch-to-batch variation in uracil purity ≤0.2%, melting point ≤1°C, and particle size distribution ≤5%. A major pvc heat stabilizers client reported zero performance issues across 100+ batches, validating the reliability of Hebei Guangxing’s uracil

 

Uracil Production FAQS

 

What is the yield of Hebei Guangxing’s uracil synthesis from urea process?

 

Hebei Guangxing’s uracil synthesis from urea process achieves a yield of ≥85% under optimized conditions (180–200°C, urea:malic acid molar ratio 2.5:1, sodium carbonate catalyst). This yield is 10–15% higher than traditional batch processes, thanks to the company’s continuous CSTR system and byproduct recycling. For industrial-scale orders (≥10 tons), the yield remains stable at ≥83%, ensuring cost-effectiveness for clients using uracil in pvc heat stabilizers or pharmaceuticals.

 

How does Hebei Guangxing ensure uracil purity for pvc heat stabilizers?

 

Hebei Guangxing ensures uracil purity for pvc heat stabilizers via two key steps: 1) Cooling crystallization (removing impurities to ≤0.5%) and 2) strict quality testing (HPLC for chromatographic purity ≥99.0%, heavy metals ≤1 ppm). The uracil is also tailored for pvc heat stabilizers with controlled particle size (80–300 μm) and surface modification (stearic acid coating) to enhance dispersion. A pvc heat stabilizers client confirmed that this uracil maintains PVC thermal stability for 180+ minutes at 180°C, meeting their production requirements.

 

Can Hebei Guangxing scale uracil production beyond 500 tons/year for large pvc heat stabilizers clients?

 

Yes—Hebei Guangxing has the capacity to scale uracil production to 1,000 tons/year by adding parallel CSTR lines and expanding raw material storage. The company’s modular production design allows for 3–6 months of ramp-up time, with no compromise on uracil quality (purity ≥99.0%, consistency ≤0.2% batch variation). A large pvc heat stabilizers manufacturer recently secured a 800 tons/year uracil supply contract, with production scaled smoothly to meet demand.

 

What are the environmental advantages of Hebei Guangxing’s uracil synthesis from urea compared to other methods?

 

Hebei Guangxing’s uracil synthesis from urea has two key environmental advantages: 1) Byproduct recycling (ammonium carbonate converted back to urea), reducing waste by 15% and raw material consumption; 2) Mild reaction conditions (atmospheric pressure, 180–200°C) that cut energy use by 25% compared to high-pressure cyanate-based methods. The process also meets ISO 14001 standards, with CO₂ captured for byproduct recycling—making it a greener choice for clients producing eco-friendly pvc heat stabilizers.

 

Does Hebei Guangxing provide technical support for clients using uracil in pvc heat stabilizers?

 

Absolutely—Hebei Guangxing provides full technical support for clients integrating uracil into pvc heat stabilizers, including: 1) Recommendations for uracil dosage (typically 0.5–2.0 phr based on PVC type); 2) Compatibility testing with other stabilizer components (calcium zinc salts, antioxidants); 3) Troubleshooting support for dispersion or thermal stability issues. A pvc heat stabilizers client in Europe used this support to optimize their formulation, reducing uracil dosage by 10% while improving PVC thermal stability by 15%.

Hebei Guangxing Chemical Co., Ltd. was established in January 2013 and is located in the ChemicalIndustrial Park of Xinhe County, Xingtai City, Hebei Province, covering an area of 90 acres.calcium zinc stabilizer manufacturer The mainproducts are 5000 tons/vear 13-dimethylurea and 6000 tons/year 6-amino-13-dimethyluracil.Hebei Guangxing Chemical Co., Ltd. was established in January 2013 and is located in the ChemicalIndustrial Park of Xinhe County, Xingtai City, Hebei Province, covering an area of 90 acres.pvc heat stabilizers The mainproducts are 5000 tons/vear 13-dimethylurea and 6000 tons/year 6-amino-13-dimethyluracil.uracils|super blog