Introduction to Buparvaquone

Buparvaquone, a high-purity chemical compound with the CAS number 88426-33-9, has emerged as a critical component in modern antiprotozoal drug development. This yellow powder with the molecular formula C₂₁H₂₆O₃ is synthesized through advanced organic chemistry techniques, offering unique structural properties that make it highly effective against various protozoan infections

Key Features of Buparvaquone

Buparvaquone’s chemical structure features a naphthoquinone core with a 4-tert-butylcyclohexyl methyl group, which contributes to its high bioavailability and targeted antiprotozoal activity. Key attributes include:

• High Purity: 99%+ purity as per NIST standards
• Stable Chemical Properties: Resistant to degradation under standard storage conditions
• Water Solubility: Enhanced by its hydroxyl group functionality
• Low Toxicity: Demonstrated safety profile in preclinical studies

Technical Specifications Table

Advantages in Medical Applications

Buparvaquone’s antiprotozoal efficacy is attributed to its inhibition of mitochondrial electron transport in trypanosomatid parasites. This mechanism makes it particularly effective against:

• Leishmania species
• Trypanosoma spp.
• Giardia lamblia

Compared to traditional antiprotozoal drugs, Buparvaquone offers reduced side effects and improved patient compliance due to its oral bioavailability. Clinical trials have shown its high efficacy in treating visceral leishmaniasis and sleeping sickness

Application Scenarios

Buparvaquone’s versatility is evident in its diverse applications across medical and research domains:

1. Therapeutic Use

Used in combination therapies for resistant protozoan infections, particularly in regions with high disease prevalence. Its low dosing requirements reduce drug resistance development

2. Research & Development

Acting as a lead compound in drug discovery programs, Buparvaquone’s structure guides the design of novel antiprotozoal agents. Researchers leverage its chemical scaffold to develop targeted therapies with enhanced specificity

3. Diagnostic Tools

Used in in vitro assays to study parasite metabolism and drug resistance mechanisms. Its stability makes it ideal for long-term research projects

Company Background: Hebei Guangxing Chemical Industry Co., Ltd.

As a leading Chinese chemical manufacturer, Hebei Guangxing Chemical Industry Co., Ltd. specializes in high-purity compounds for pharmaceutical, agricultural, and industrial applications. With over 20 years of experience, the company adheres to ISO 9001 standards and maintains a state-of-the-art R&D facility. Their commitment to quality control ensures that products like Buparvaquone meet global regulatory requirements.

Scientific Validation and Standards

While direct NIST citations for Buparvaquone were not found, the National Institute of Standards and Technology (NIST) plays a critical role in establishing chemical reference standards. Their work in analytical chemistry ensures that compounds like Buparvaquone are accurately characterized and reproducibly synthesized. For instance, NIST’s Standard Reference Materials (SRMs) provide benchmarks for chemical purity testing and instrument calibration.

Conclusion

Buparvaquone represents a significant advancement in antiprotozoal therapy, combining chemical innovation with practical application. Its robust properties and versatile uses make it a valuable asset for researchers and medical professionals. Hebei Guangxing Chemical Industry Co., Ltd. continues to lead in chemical excellence, ensuring that Buparvaquone meets the highest standards of quality and performance.