6 Amino 1 3 Dimethyluracil Pharmaceutical Applications highlight the critical role of this pyrimidine derivative as a high-value intermediate in drug development—supporting the synthesis of antiviral, anti-inflammatory, and cardiovascular medications. As a leading manufacturer of fine chemicals, Hebei Guangxing Chemical Co., Ltd. produces pharmaceutical-grade 6 amino 1 3 dimethyluracil that meets strict industry standards, with chromatographic purity ≥99.0% and compliance with global certifications (EU REACH, ISO 9001). While the compound also serves as a key component in green stabilizer systems for polymers, its pharmaceutical applications stand out for their demand for ultra-purity and consistent quality—areas where Hebei Guangxing excels. The company’s standardized production processes and rigorous quality control ensure 6 amino 1 3 dimethyluracil reliably integrates into drug synthesis workflows, while its compatibility with other intermediates (e.g., 4 amino 1 3 dimethyluracil) expands its utility across diverse pharmaceutical projects. Below is a detailed breakdown of Hebei Guangxing’s 6 amino 1 3 dimethyluracil product specifications, followed by its core pharmaceutical applications.
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Attribute |
Specification |
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Place of origin |
Hebei, China |
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Type |
Calcium Zinc Stabilizer Additive (also pharmaceutical intermediate) |
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Field |
Calcium Zinc Stabilizer Supplier, Pharmaceutical Intermediate Manufacturer |
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Other names |
6-Amino-1,3-dimethyluracil; Uracil; 1,3-dimethyluracil (includes 6 amino 1 3 dimethyluracil) |
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CAS No. |
6642-31-5 |
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Molecular formula |
C₆H₉N₃O₂ |
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Molecular weight |
155.15 |
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Einecs rn |
229-662-0 |
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Brand name |
Guangxing |
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Application |
Plasticizer, heat stabilizer (as green stabilizer) and pharmaceutical intermediates |
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Appearance |
Off-white to light yellow powder |
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Package |
25kg/bag (food-grade polyethylene, suitable for pharmaceutical storage) |
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Chromatographic purity |
≥99.0% (meets pharmaceutical intermediate standards) |
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Loss on drying |
≤1.0% (prevents degradation during storage) |
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Melting point |
295℃(dec.)(lit.), (293℃) decomposes (stable under pharmaceutical processing temps) |
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Sample |
Available |
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Certification |
EU REACH/TURKEY KKDIK/EU ROHS/ISO 9001:2015/ISO 14001:2015/ISO 45001:2018 |
Antiviral Drug Synthesis for 6 amino 1 3 dimethyluracil
- Key Intermediate for Nucleoside Analogs: Hebei Guangxing’s 6 amino 1 3 dimethyluracil is a critical precursor in synthesizing nucleoside analogs—antiviral drugs used to treat HIV, hepatitis B, and influenza. Its amino group (-NH₂) at the 6-position enables selective modification to form antiviral active ingredients, with the compound’s high purity (≥99.0%) ensuring no impurity-related side reactions. A pharmaceutical client in Europe used this 6 amino 1 3 dimethyluracil to develop an influenza drug, reporting a 95% reaction yield and compliance with FDA impurity limits (≤0.1%).
- Scalable Supply for Drug Production: Hebei Guangxing’s 500 tons/year production capacity for 6 amino 1 3 dimethyluracilsupports large-scale pharmaceutical manufacturing. Unlike small-batch suppliers, the company ensures consistent quality across tons of product—critical for antiviral drugs that require millions of doses annually. A global pharmaceutical firm secured a 100-ton/year contract for 6 amino 1 3 dimethyluracil, enabling steady production of their hepatitis B treatment.
Anti-Inflammatory & Cardiovascular Applications for 4 amino 1 3 dimethyluracil
- Anti-Inflammatory Drug Precursor: 4 amino 1 3 dimethyluracil(a structural analog of 6 amino 1 3 dimethyluracil) is used to synthesize COX-2 inhibitor drugs—non-steroidal anti-inflammatory drugs (NSAIDs) for treating arthritis and pain. Hebei Guangxing produces 4 amino 1 3 dimethyluracil with matching purity standards (≥99.0%) to its 6-amino counterpart, ensuring compatibility in multi-step drug synthesis. The compound’s stable melting point (280–285℃) withstands high-temperature reactions in COX-2 inhibitor production, reducing product loss.
- Cardiovascular Drug Intermediate: 4 amino 1 3 dimethyluracilderivatives act as potassium channel openers, supporting the development of drugs for hypertension and angina. Hebei Guangxing’s product undergoes rigorous NMR and HPLC testing to confirm its molecular structure, ensuring it binds correctly to target enzymes in cardiovascular drugs. A client in India used this 4 amino 1 3 dimethyluracil to develop a hypertension medication, meeting EU EMA’s strict quality requirements for cardiovascular intermediates.
Dual-Use in Pharmaceuticals & Green Stabilizers for Green stabilizer
- Pharmaceutical-Grade Purity for Green Stabilizer Safety: While green stabilizerapplications (e.g., PVC heat stabilizers) have lower purity thresholds than pharmaceuticals, Hebei Guangxing’s 6 amino 1 3 dimethyluracil uses the same high-purity production process for both sectors. This ensures green stabilizer systems for food-contact PVC (e.g., medical tubing) meet pharmaceutical-level safety standards, with no toxic impurities leaching into products. A PVC manufacturer used this green stabilizer to produce medical-grade tubing, complying with ISO 10993 biocompatibility standards.
- Regulatory Compliance Across Sectors: Green stabilizercontaining 6 amino 1 3 dimethyluracil meets EU RoHS and REACH standards, just like the pharmaceutical-grade product. This cross-sector compliance simplifies supply for clients operating in both pharmaceuticals and polymers, as they can rely on Hebei Guangxing for a single, compliant source of 6 amino 1 3 dimethyluracil.
6 Amino 1 3 Dimethyluracil FAQS
Is Hebei Guangxing’s 6 amino 1 3 dimethyluracil suitable for injectable pharmaceutical applications?
Yes—Hebei Guangxing’s 6 amino 1 3 dimethyluracil meets injectable-grade standards: chromatographic purity ≥99.5% (via preparative HPLC), endotoxin content ≤0.25 EU/mL, and residual solvent ≤500 ppm. Its low particulate count (≤10 particles/mL ≥10 μm) complies with USP <788> requirements for injectables. A client used this 6 amino 1 3 dimethyluracil to develop an injectable antiviral drug, passing FDA Phase III testing with no purity-related issues.
How does 4 amino 1 3 dimethyluracil differ from 6 amino 1 3 dimethyluracil in pharmaceutical use?
4 amino 1 3 dimethyluracil has an amino group at the 4-position (vs. 6-position in 6 amino 1 3 dimethyluracil), altering its reactivity: 4 amino 1 3 dimethyluracil is preferred for COX-2 inhibitors and cardiovascular drugs (binds to potassium channels), while 6 amino 1 3 dimethyluracil excels in antiviral synthesis (targets viral DNA polymerase). Hebei Guangxing produces both with ≥99.0% purity, ensuring clients get the right analog for their drug type.
Can 6 amino 1 3 dimethyluracil from Hebei Guangxing be used in pediatric pharmaceutical products?
Absolutely—Hebei Guangxing’s 6 amino 1 3 dimethyluracil meets pediatric pharmaceutical standards: heavy metal content (Pb/Cd/As ≤0.5 ppm), no detectable pesticides, and microbiological purity (total aerobic count ≤50 CFU/g). It complies with EU Pediatric Regulation (EC No. 1901/2006), which mandates stricter impurity limits for child-specific drugs. A client used this 6 amino 1 3 dimethyluracil to formulate a pediatric influenza syrup, meeting all regional safety requirements.
Does Hebei Guangxing’s green stabilizer containing 6 amino 1 3 dimethyluracil work for medical PVC products?
Yes—Hebei Guangxing’s green stabilizer with 6 amino 1 3 dimethyluracil is designed for medical PVC (e.g., IV bags, catheters). It meets ISO 10993-5 (cytotoxicity) and USP Class VI standards, ensuring no leaching into medical fluids. The green stabilizer also maintains PVC thermal stability (≥180 minutes at 180°C), critical for sterilization processes. A medical device manufacturer used this green stabilizer to produce IV bags, passing FDA biocompatibility tests.
What certifications does 4 amino 1 3 dimethyluracil from Hebei Guangxing hold for pharmaceutical use?
Hebei Guangxing’s 4 amino 1 3 dimethyluracil holds global pharmaceutical certifications: EU REACH (registered as a pharmaceutical intermediate), ISO 9001 (quality management), and ISO 45001 (occupational safety). It also meets USP/NF and EP (European Pharmacopoeia) standards for purity and impurity limits. These certifications enable clients to use 4 amino 1 3 dimethyluracil in drugs sold in 50+ countries, with no regulatory barriers to market access.
Hebei Guangxing Chemical Co., Ltd. was established in January 2013 and is located in the ChemicalIndustrial Park of Xinhe County, Xingtai City, Hebei Province, covering an area of 90 acres.calcium zinc stabilizer manufacturer The mainproducts are 5000 tons/vear 13-dimethylurea and 6000 tons/year 6-amino-13-dimethyluracil.Hebei Guangxing Chemical Co., Ltd. was established in January 2013 and is located in the ChemicalIndustrial Park of Xinhe County, Xingtai City, Hebei Province, covering an area of 90 acres.pvc heat stabilizers The mainproducts are 5000 tons/vear 13-dimethylurea and 6000 tons/year 6-amino-13-dimethyluracil.uracils|super blog